• Transactions » | Injuries » Leagues drafted before the first game of the week will begin play immediately, while leagues drafted after the first game will start the following week. ET | Fox Matchup rating: 85.5 | Spread: KC -5 (57.5), What to watch for: Bills wide receiver Stefon Diggs is averaging a career-high 101.8 yards per game in 2020, good for second in the NFL. See Week 6 rankings. What to know for fantasy: Bengals running back Joe Mixon is on pace for 384 touches this season, a number that only Ezekiel Elliott, Le'Veon Bell, Christian McCaffrey and Derrick Henry have hit since 2015. NFL experts debate their title window, future at QB, 2021 NFL draft order: Top 28 picks set, with Jags, Jets, Dolphins at the top, What separates Watson and Mahomes? Prior to that, Detroit had been 4-18 straight up and 6-16 ATS in its previous 22 meetings against Green Bay. Can Saints add Fournette to their under-100 club? -- Ben Baby. Stat to know: The Cowboys have 11 turnovers this season, tied for most in the NFL. Start in the red zone ... No longer 'Marvin'? Matchup rating: 42.2 | Spread: CAR -1.5 (44.5), What to watch for: This game is all about pressure. -- Lindsey Thiry, Bold prediction: Kyle Shanahan and Sean McVay are known for their offensive acumen, and these teams average a combined 61 points per game. SB Nation NFL Expert Picks, Week 6: Bears vs. Panthers is the most intriguing matchup of the week. -- Tim McManus, Bold prediction: Ravens quarterback Lamar Jackson will throw at least four TD passes. The Chiefs, on the other hand, have allowed two 100-yard receivers through five games this season. ET | CBS -- Jenna Laine, • McShay's most recent mock draft » Jaguars 24, Browns 6. What to know for fantasy: Jackson had just one game last season with fewer than 19 fantasy points. Betting nugget: Tennessee is 3-11 ATS in games that follow fewer than six days' rest since the start of the 2013 season. 0 of 14. Donald is capable of wrecking games by himself, and the Niners' interior line has been of particular concern. What to know for fantasy: Carolina running back Mike Davis has a 15-yard rush, a 10-yard reception and at least five receptions in three straight games. -- John Keim. Read more. -- Mike Wells, Create a new league today and start fresh from this point! And he is 2-0 this season. ET | ESPN They average just 67 rushing yards per contest, 28th in the NFL. In our picks and predictions for Week 6 of the 2020 NFL season, and the Browns-Steelers AFC North rivalry is a tough pick. If not, it could be another long day for the Browns. Stat to know: Colts quarterback Philip Rivers has thrown four passing touchdowns this season, the fewest through his team's first five games of a season in his career. What to know for fantasy: Tyler Boyd ranks fourth in the NFL with 53 targets and is playing for a Bengals team that is dropping back to pass at the third-highest rate (71%). 1 receiver: Vikings' Thielen relishing new roles, 1 p.m. Matchup rating: 28.7 | Spread: MIA -10 (47), What to watch for: The Dolphins are favored for the first time in 21 games (December 2018) and favored by more than a touchdown for the first time since November 2016. ... Texans' Lunch Pail Crew eats up blocks for Watt, Mercilus, 1 p.m. The Chargers have one of the better pass defenses in the league, but third-string QB Hodges isn't afraid to throw the ball. 12 to No. Betting nugget: Over the past two seasons, Atlanta is 6-15 ATS, the worst record in the NFL. Experts weigh in with analysis and provide premium picks for upcoming NFL games. The Cowboys are well aware of what he means to Arizona's offense. Christian McCaffrey did not have such a streak last season. Stat to know: Minshew needs 235 passing yards to have the most ever by a Jaguars QB through six games. Read more. Our NFL Nation reporters bring us the keys to every game, a bold prediction for each matchup and final score predictions. ET | CBS Ben Axelrod's Week 6 NFL picks: Panthers beat Bears, Cowboys upset Cardinals WKYC's Ben Axelrod makes his picks against the spread for every game in Week 6 of the 2020 NFL season. FPI prediction: NE, 63.6% (by an average of 4.8 points), Matchup must-reads: "A student of everything": What a 26-year-old Bill Belichick learned as a Broncos assistant ... Patriots' Newton comes off COVID-19 list ... Broncos coach Fangio forced to take more risks on defense ... Broncos RB Gordon cited for DUI, 1 p.m. It's been a rough start for Thomas, as he's ranked 61st out of 68 tackles in pass-block win rate (79.4%), an ESPN metric powered by NFL Next Gen Stats. Read more. What to know for fantasy: Bucs receiver Chris Godwin has finished three weeks as a top-10 receiver this season, while teammate Mike Evans has finished outside of the top 45 on three occasions. 4 overall selection. Matchup rating: 74.6 | Spread: MIN -3 (44), What to watch for: The Eagles are coming off a 10-sack performance, while the Vikings harassed Giants quarterback Daniel Jones last weekend with aggressive blitzes. He is averaging 3.95 yards per rush over his past four games after rushing for 97 yards (7.46 per rush) in Week 1. One of the things the Colts, who have the NFL's No. Humphrey making big name for himself ... Bengals leaning on strong connections while trying to snap winless start ... From picks to deep passes: Jackson's learning curve still steep, 1 p.m. NFL Week 6 picks: All the rest. That stat line isn't too far from what Allen has done through five games this season: 69% passing, 1,589 yards, 14 touchdowns, three interceptions and an 85.2 Total QBR. What to know for fantasy: Wilson leads the league in touchdown pass percentage (7.7%) and is in search of his third straight season finishing as a top-three player in that metric. 12 to No. FPI prediction: NO, 57.8% (by an average of 2.7 points), Matchup must-reads: Florida Man 2.0: Behind Minshew's mustache lie 'genius tendencies' ... Can Saints add Fournette to their under-100 club? How have the Titans' free-agent additions fared? The tide has turned in recent weeks, however, as Mixon posted a 6-30-1 line in Week 4 and a 6-35-0 line this past Sunday. The Titans have surrendered eight touchdowns in the passing game this season, and four of those have been to opposing tight ends. Rookie Fant trying to smooth out the 'rough spots'. McClure's pick: Falcons 28, Cardinals 21 This is the 1st best out of all 34 experts. On the flip side, Burrow has been sacked more than any other QB in the NFL. What to know for fantasy: Kyler Murray had just 17 total rushing yards in his first two career games, but he's racked up at least 27 in each of the three games since, and his 16-game pace over those three games is that of a 1,000-yard rusher. Matchup rating: 56.2 | Spread: CAR -2 (47), What to watch for: Shaquil Barrett likely won't be rendered sackless two weeks in a row, especially against the team that allowed him three sacks in one quarter in Week 2. Plus, Los Angeles gets the best of San Francisco, and slipping Kansas City and Dallas get back on track. See Week 6 rankings. Pick NFL winners straight up or against the spread and compete to win more than $14,000 in prizes! Miami is the NFL's worst run defense at 176 yards per game. Can a banged-up Cleveland secondary finally force him into turnovers? Cleveland (plus 17) at Jacksonville: The Jaguars have only one more game left with a winning team. NO-JAX | SEA-CLE | CIN-BAL But the Falcons will also be trying to avoid their worst six-game start since 2007 (1-5), the season before they drafted Ryan. That could spell trouble for a Rams defense that ranks 15th at stopping the run (107 yards per game). The 12 teams combined to average 25.3 points a game in the opening round, the most since 2013. Matchup rating: 28.0 | Spread: ATL -2.5 (51), What to watch for: The Cardinals figured out how running the ball can lead to victory. Aaron Rodgers & Co. have carried the team to a 4-0 start, but after a bye week to figure out what has gone wrong, Mike Pettine's defense will find a way to come up big. 18 in the NFL, and have given up more than 190 rushing yards in a game twice. And we will update as necessary if things change. CAR-TB | HOU-KC | PHI-MIN Matchup rating: 60.6 | Spread: DEN -2.5 (41), What to watch for: Noah Fant and Jeff Heuerman should be targeted a lot. But should things remain quiet, here is a look at NFL Week 6, with all picks made against the point spread. FPI prediction: GB, 65.8% (by an average of 5.6 points), Matchup must-reads: How Packers' Matt LaFleur is doing what other first-year coaches haven't: win ... Against Packers, Lions can lean on Patricia's success against top offenses ... Packers' good vibrations: Rodgers likes 'the vibe on this team' ... Rewriting the Rodgers narrative, according to his backup center, 9:30 a.m. Additionally, ESPN Stats & Information provides a stat to know for each game, and the Football Power Index (FPI) goes inside the numbers with a matchup rating (on a scale of 1 to 100) and a game projection. Archer's pick: Cowboys 26, Jets 13 Against this line, Washington's pass rush will get healthy. What to know for fantasy: Cardinals running back Chase Edmonds has 6.8 more points this season than Kenyan Drake ... on 54 fewer touches. His low through six games is seven (2007 and 2011). The Week 6 NFL schedule is stacked with great matchups. FPI prediction: DET, 60.2% (by an average of 3.6 points), Matchup must-reads: What's wrong with Stafford's feet? See Week 6 rankings. ... Titans deal unhappy LB Correa to Jaguars ... Jaguars to use fifth kicker of season in Brown ... Jaguars among NFL teams using silver to fight COVID-19, 1 p.m. 1-ranked offense and a two-game losing streak versus the No. ET | CBS One reason for the string of victories: Mayfield has tossed two touchdown passes in all of those four wins, his longest multi-TD streak since his five straight games back in 2018. NFL B/R Expert Consensus NFL Picks for Week 6 NFL Staff Contributor I October 10, 2019 Comments. NFL experts predict: Week 6 upset picks, fantasy sleepers, disappointing players, more 1 Related Johnson: If the Dolphins scoring 43 in Santa Clara wasn't evidence enough of the 49ers' struggling and depleted defense, I don't know what is. Triplett's pick: Saints 23, Jaguars 20 Betting nugget: Dak Prescott is 7-2-1 ATS in his career when favored by six or more points (10-0 outright). Betting nugget: Green Bay is 4-0 ATS, making it the only undefeated team ATS left this season. What to know for fantasy: In a matchup of two of the worst teams in terms of offensive snaps with a lead this season, it's worth noting that Terry McLaurin has been targeted four times when Washington was leading and turned it into three catches for 104 yards and a touchdown. Do the Falcons uncover a new identity or form of motivation to rattle off a series of wins under interim coach Raheem Morris? And the Buccaneers pass on just 60.2% of plays, the 20th-highest rate in the league. The Texans, who are 12th in the league in scoring defense allowing 22 points per game, offer a significant challenge. See Week 6 rankings. Matchup rating: 14.8 | Spread: DET -3 (55), What to watch for: Look for Jaguars running back James Robinson to carry the ball more than 20 times. Stat to know: Wentz has gone four consecutive games with a completion percentage south of 60%, the longest active streak in the NFL and the longest by an Eagles starting quarterback since Mike McMahon went seven straight starts in 2005. -- Courtney Cronin, Bold prediction: Falcons quarterback Matt Ryan will throw three touchdown passes, tripling his total from the past three weeks combined. Read more. -- Sarah Barshop. Our NFL Nation reporters bring us the keys to every game, a bold prediction for each matchup and final score picks. Dickerson's pick: Panthers 17, Bears 16 It ranks fifth in sacks with 15, but eight occurred in the opener. -- Nick Wagoner, Bold prediction: Donald will turn in his third multi-sack performance of the season. Could the Bears really move to 5-1? Stat to know: The Titans are the only team that has yet to see an offensive drive end in a turnover this season. NFL Week 6 odds, picks: Patriots beat up on Giants, Chiefs rebound against Texans, plus other best bets Other best bets include the Lions hanging tough vs. the Packers Wolfe's pick: Washington 23, Miami 19 Baby's pick: Ravens 35, Bengals 14 Unhappy LB Correa traded by Titans to Jaguars ... Texans hire search firm to assist GM search, 1 p.m. So will the Steelers lean on James Conner and the running game to help protect rookie quarterback Devlin Hodges? Matchup rating: 39.1 | Spread: DAL -7.5 (45), What to watch for: It's the No. Legwold's pick: Broncos 17, Titans 13 Top Week 6 NFL expert picks. NFL experts debate their title window, future at QB, 2021 NFL draft order: Top 28 picks set, with Jags, Jets, Dolphins at the top, NFL experts predict: Week 6 upset picks, fantasy sleepers, disappointing players, more, Week 6 Love/Hate: Reinvent your fantasy football season with a new format, Projected 2021 NFL draft order: Jaguars clinch No. The Rams, after last week's close loss to Seattle, have dropped to 17th. -- Jeff Dickerson. Something has to give! Pickwatch tracks NFL expert picks and millions of fan picks for free to tell you who the most accurate handicappers in 2020 are at ESPN, CBS, FOX and many more are, straight up and against the spread. Yet the only 49ers player with multiple rushing touchdowns this season is Jeff Wilson Jr. (four), who averages 2.9 yards per rush. He has rushed for a score in all three of those games, and he even caught a touchdown last weekend at Washington. Corey Perrine/Getty Images. • Mahomes chief practitioner of free play -- Turron Davenport. In our NFL picks against the spread for Week 6, Seattle wins a close game in Cleveland. The Titans will also have Jeffery Simmons back to team up with Jadeveon Clowney on the inside, with Vic Beasley Jr. and Harold Landry III coming off the edge in their NASCAR package. ET | CBS 2: Packers want second Super Bowl for Aaron Rodgers, Marv Levy, Cornelius Bennett, former Bills eager to see Buffalo 'finally' win title, Who stays and who goes? FPI prediction: KC, 66.8% (by an average of 6.0 points), Matchup must-reads: What separates Watson and Mahomes? ET | Fox Teacher, coach, No. See Week 6 rankings. This is the percentage of the general public betting on each side of a matchup or total. The scheme might not change, but what kind of stops does Atlanta pull out against a Vikings team scratching to keep its playoff hopes alive? The Week 17 NFL schedule is stacked with great matchups. CIN-IND | DET-JAX | WSH-NYG Matchup rating: 37.4 | Spread: ARI -1.5 (55), What to watch for: Cardinals quarterback Kyler Murray is 6-0 all time at AT&T Stadium. They haven't won back-to-back games by double digits since 2015, before the Brian Flores and Adam Gase eras in Miami, while the Jets have lost every game this season by at least nine points. What to know for fantasy: In his first season without DeAndre Hopkins, Watson is on pace to set new career highs in both passing touchdowns and passing yards. ARI 8-8 38. ET | NBC The Week 6 NFL slate is stacked with great matchups. One out of … Betting nugget: San Francisco is 0-3 ATS and straight up at home this season. OK, when it's put that way, it might not sound bold, but the one time he didn't reach that total this season came against Tampa Bay, which held him to a season-low 53 yards from scrimmage. Can the Panthers, who have not allowed a sack in two straight games, keep quarterback Teddy Bridgewater clean against Chicago's Akiem Hicks and Khalil Mack, who have 3.5 sacks each? Week 6 NFL picks, odds, TV: Texans send Chiefs to second straight loss, Eagles upset Vikings in Minnesota Picks for every Week 6 game, including … DET-GB, Thursday: NE 35, NYG 14 Last week’s record: 9-5 They're 28th in third-down percentage, and the Miami defense is seventh. Create or join a league today >>, Bold prediction: The Colts will have a plus-five sack differential. One huge stat, Mahomes says ankle injury won't limit his mobility vs. Texans. Rookie running back Clyde Edwards-Helaire accounted for 161 of the Chiefs' 245 rushing yards as Kansas City came out victorious. Of … Trotter's pick: Steelers 28, Browns 24 The matchup in pass protection is heavily tilted toward the Colts. ET | CBS By the fourth quarter, it could be a two-touchdown game and the stadium will be overrun by Dallas fans. See Week 6 rankings. Matchup rating: 40.9 | Spread: BAL -12 (47.5), What to watch for: Baltimore averages 36 runs per game, a monumental challenge for Cincinnati, which has given up the second-most rushing yards this season (167.6 per game). He caught 11 of 13 targets for 65 yards and a touchdown in his two games against the Steelers last season. 1 pick, Dolphins move into top five, D is the new MVP: Ravens' D upstaging Jackson, From QB play to his contract, a look at what's ailing Eagles' Ertz, Eagles cleared to host limited fans at home games, "Biggest" Eagles fan sends well-wishes after Prescott's injury, Hurting Browns QB Mayfield still plans to face Steelers, Browns vs. Steelers: Behind the turnarounds, return of Garrett and what win means, Browns' Garrett playing at elite level going into Steelers rematch, Steelers coach Mike Tomlin focused on facing Browns, not Garrett, Steelers' Roethlisberger "proud" of Smith-Schuster's selflessness, Titans have been dominating in the red zone behind Tannehill, Unhappy LB Correa traded by Titans to Jaguars, Texans hire search firm to assist GM search, Falcons shut down facility after positive coronavirus test, Vikings' Mattison ready to step in for injured Cook, Teacher, coach, No. -- Vaughn McClure. 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